Mutagen and Oncogen Study on RJ-5.

摘要

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. The test material did not exhibit mutagenic activity in microbial, cell culture or in vivo assays. Evidence for repairable nonspecific DNA damage was obtained. This observation, while indicating the potential of RJ-5 to interact with mammalian DNA, does not constitute evidence for significant risk associated with exposure to the material. Without concommitant demonstration of mutagenicity, the significance of the unscheduled DNA synthesis data is clearly reduced. (Author)