Mutagen and Oncogen Study on 4,4-Dioctyldiphenylamine.

摘要

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. 4,4-Dioctyldiphenylamine was not active in most of the assays conducted in this evaluation and the evidence for its activity in the unscheduled DNA synthesis and rat dominant lethal assays was limited to marginal effects. No clear trends showing significant genetic potential were obtained from this evaluation. While the compound cannot be classified as without genetic activity, the type of positive data obtained does not warrant a conclusion that the test compound represents a serious genetic or carcinogenic risk to mammals. (Author)