Unsteady-State Response of the Vascular System to Transient and Sustained Aerospace Acceleration Profiles.

摘要

In this study a mathematical method to determine the response of the blood vessels to transient and sustained acceleration forces is presented. The method is based on coupling of the Navier-Stokes equations for blood flow and the large elastic deformation theory for the deformation of the blood vessels, and solving them numerically under the appropriate initial and boundary conditions. A mathematical reasoning to neglect the effect of acceleration on microcirculation per se is given. However, microcirculation is indirectly affected by acceleration forces which tend to pool blood and bring about pressure changes in large vessels. Aortic pressures are calculated for examples of monotonically increasing and transient -Gz acceleration profiles, and one of the solutions is compared with an available, experimentally measured pressure from an animal experiment. In the absence of proper physiological scaling laws, the qualitative agreement between the theory and experiment is satisfactory. (Author)