Ethanol-Induced Changes in Performance and Mood in Relation to Acquired Tolerance in Social Drinkers.

摘要

The purpose of this study was to evaluate the usefulness of two measures of performance and one measure of mood as indicators of degree of acquired tolerance to ethanol in social drinkers. Eleven social drinkers (2 light, 4 moderate, 5 heavy) participated in 8 hours of repetitive testing on each of 2 nonconsecutive days, placebo and drug. Ethanol induced significant alterations in mood, and significant decreases in serial reaction time and Stipple-cancellation performance, but none of these changes correlated significantly with drinking history. Evidence is considered that the present ethanol dosage (0.9g/kg) may not have been sufficient, that a wider range of drinking histories was needed, and that electrophysiological/psychophysical measures may be more useful than the present performance and mood tests in the search for measures of acquired tolerance to ethanol in social drinkers. (Author)