Early Support of Intracranial Perfusion.

摘要

This report represents the fifth in a multi-year effort to improve outcomes in patients with traumatic brain injury (TBI) utilizing human and animal models. The first two years focused on infrastructure development, development of a basic science protocol, development and institution of two human use protocols, staff acquisition, equipment purchase and development of a Brain Resuscitation Registry (BRR) to provide structure and linkage capabilities for data collection and outcome reporting. Year 3 accomplishments included the ongoing enrollment of subjects in the human use protocols focusing on the inflammatory process following TBI and vital sign response to trauma, development and implementation of 2 retrospective human use protocols, processing of specimens for the Cytokines sub-project, further development of the BRR and initiation of the basic science model including both small and large animal models of polytrauma. During Year 4 the existing human use protocols concluded data collection and neared finalization of data analysis, and a new protocol was proposed. Progress continued in BRR development and reporting, and the animal sub-project neared completion. Year 5 saw completion of data analysis for the Cytokines and Animal sub-projects, ongoing analysis of the Vital Signs sub-project, and continued development of the final human use sub-project. A no-cost extension was granted in September 2012, to allow for completion of the final human use protocol.