Liver Redox Resistance, a Dynamic Model of Gluconeogenic Lactate Metabolism.

摘要

For isolated hepatocytes from starved rats metabolising lactate, the time curves of pyruvate and glucose produced and lactate remaining are fitted with elementary mathematical functions by simple statistical procedures. The fitted functions are very close approximations to the solutions of differential equations which express the following model: (i) The rate of net pyruvate production, which involves hydrogen disposal, is proportional to the rise of cytoslic redox potential. (ii)Glucose is produced at a rate proportional to the concentration of pyruvate, the initial substrate in the chain of reactions. (iii) The lactate remaining is that part not transformed into pyruvate or glucose less a small amount progressively transformed into other substances or catabolised. Since the rise of redox potential is measured in volts and the net hydrogen flux from the lactate can be expressed in amps of electron flow involved, the ratio ohmns is called a redox resistance. The estimated flux curves for hydrogen and gluconeogenic intermediates are shown. (Author)