5-Thio-D-Glucose: Thermoregulatory Effects in Mice at Various Environmental Temperatures.

摘要

Adult, male mice were administered various doses of 5-thio-D-glucose (5-TG) at three environmental temperatures: 4 C, 22 C, and 35 C. Both intracerebroventricular (ICV) and intraperitoneal (IP) administration of 5-TG resulted in significant (p less than .05 to p less than .001) decreases in rectal temperature (Tre) which were usually dose-dependent. After 30 min the hypothermic effects were significantly (p less than .001, ICV, 100 microgram) exacerbated by cold exposure (4 C vs 22 C) and were likewise intensified significantly (p less than .005, 45 min, fed vs 18 h fasted) by food deprivation. These decrements in rectal temperature (Tre) were accompanied by significcant (p less than .001) increases in circulating levels of glucose. The present results indicate that 5-TG may be eliciting both central and peripheral cellular glucopenia concomitant with circulatory hyperglycemia; thus, the resultant hypothermia may be arising from competitive inhibition of glycolysis by 5-TG intermediates as well as reduced availability of tissue glucose.