Durability Methods Development. Volume V. Durability Analysis Methodology Development

摘要

Orthochloronitrobenzene (OCNB) is a trace contaminant in Otto Fuel II (OFII), a nitrated ester used as a torpedo propellant by the U.S. Navy. In a published study, OCNB has been reported to produce multiple life tumors in male and female rats. The quantification of OCNB in OFII was performed by high pressure liquid chromatography. The OFII was performed by high pressure liquid chromatography. The OFII was found to contain 0.00165% ONCB and a distillate of OFII was found to contain 0.0009% OCNB. It was estimated that over a 12 month inhalation exposure to 240 mg/cum of OFII an animal would receive a total dose of 0.05 mg OCNB kilogram of body weight. This is insignificant compared to the total dose required for the previously published results. OCNB is not considered to be a factor in the outcome of the current studies. (Author)