Role and Regulation of FOXD3 in Mutant B-RAF Melanoma.

摘要

The high level exposure of our troops to ultraviolet (UV) radiation increases their risk of melanoma. Notably, melanoma is the second most common cancer in males in the US Navy. Melanoma is an extremely aggressive disorder. Once invasive, it rapidly metastasizes to distant organs, the response to chemotherapeutic regimens is poor, and the five year survival rate is low. Thus, new chemotherapeutic strategies must be devised to reduce the numbers of our military, veterans and members of the general public succumbing to melanoma. We aim to understand resistance mechanisms in melanoma in order to provide the basis for improved targeted therapeutic strategies.