Implantation and Maintenance of Chronic Jugular Venous Catheters in Rhesus Monkeys (Macaca mulatta)

摘要

The study of neuroendocrine parameters in rhesus monkeys and other laboratory animals is complicated by the fact that procedures often used to obtain blood samples from the animals cause rapid and pronounced changes in the circulating levels of a number of hormones. Several reports in the open scientific literature indicate that this problem can be greatly reduced or eliminated through the use of chronically indwelling venous catheters. An effort was undertaken to adapt published procedures for such catheters for use in this laboratory. Procedures have been successfully adapted for the implantation, maintenance, and extended use of chronic indwelling jugular venous catheters in rhesus monkeys. These catheters have been successfully used to draw blood samples from chair-restrained monkeys without any interaction with the animal. (Author)