Chemotherapeutic Studies on Schistosomiasis and Clinical, Epidemiological and Immunological Studies on Malaria in Amazonas, Brazil, along the Ituxi River. Report Number VII

摘要

The U.S. Army's Anti-Schistosome Drug Development Program, provides selected drugs for testing in mice. The compounds are tested for prophylactic (PMT) or curative (PCT) activity as a primary screen according to pre-established priorities. The program is supported by a Biomphalaria glabrata snail colony capable of providing a daily inventory of 1,000 to 1,500 S. mansoni infected snails. The malaria research program at the Univ. of Brasilia emphasizes investigations of the clinical, epidemiological, immunological and entomological aspects of this disease in a population residing along the Ituxi River in Amazonas, Brazil. The major laboratory and field activities include clinical examination of individual patients for signs of disease, seroepidemiological studies, in vitro chloroquine susceptibility testing of local strains of Plasmodium falciparum, the study of the ecology and population dynamics of malaria vectors, with special emphasis on Anopheles darlingi Root, and investigation of the role of euglossine bees in the removal of DDT from sprayed houses. These studies of malaria, in a region known to be 'refractory' to control measures, are designed to collect information which will contribute to an understanding of the mechanisms or continued disease transmission in spite of ongoing eradication efforts. Extensive investigation were conducted on host seeking behavior of An. darlingi in DDT-sprayed and unsprayed houses and analysis of the results relative to the incidence of malaria in the Amazonas study area.