Isolation and Characterization of Plasmodial and Babesial Antigens

摘要

The continuous flow sonic system developed in this laboratory and various other methods for freeing malaria parasites from their host erythrocytes were evaluated from the standpoint of the morphological integrity of the freed parasites and the utility of the freed parasites as sources of antigen for immune and serological tests. Our attempts to identify which antigens are protective by immunization have demonstrated that a soluble component of Plasmodium berghei is significant in inducing immunity, and we have tentatively identified this soluble component as surface coat material. Thus our work on identification of protection stimulating antigens in Plasmodium benghei has been successful. The knowledge obtained from these studies must now be applied to development of a vaccine against malaria of man. (Author)