Chemical Index to Fitness

摘要

Studies accomplished under this contract included both independent studies at the Harbor-USLA Medical Center, Torrance, CA 90509, and collaborative studies of Navy personnel conducted with the Naval Health Research Center, San Diego, CA. The focus of these studies was on the regulation of anterior pituitary hormones, both under stress conditions and under conditions of neurotransmitter manipulation, and their subsequent effects on peripheral target gland hormones. Included in the studies were an acute stress study of prolactin secretion, a chronic stress study of cortisol and testosterone secretion, and the effects of dopamine receptor blockade and thyrotropin releasing hormone administration on anterior and posterior pituitary hormones. The aforementioned studies all were done in human subjects. Some studies also were done in laboratory animals, as they could not be accomplished in humans. These included the hormonal manipulation of neonatal laboratory rats, in order to investigate the maturation of the circadian rhythms of anterior pituitary hormones and their responsiveness to stress in later life.