Evaluation of Short-Term Bioassays to Predict Functional Impairment. Development of Renal Bioassays in Laboratory Animals, Directory of Institutions/Individuals

摘要

MITRE has been requested by the U.S. Army Medical Bioengineering Research and Development Laboratory to identify and evaluate short-term bioassays which have demonstrated ability to evaluate and predict renal impairment resulting from toxicant exposures. This directory is a companion to Selected Short-Term Renal Toxicity Tests, which describes the available renal testing protocols and assesses their suitability for a screening program. This directory catalogues the organizations currently engaged in renal bioassay utilization or development and provides information concerning specific measurements performed, test systems employed, compounds tested, requirements for anesthesia and terminal nature of the test. The companion report to this directory reviews the literature on test procedures for determining effects on the kidneys and other components of the renal system. The procedures are discussed in sections on morphology, glomerular function, tubular function, intrarenal hemodynamics, and biochemistry. Criteria for evaluating these procedures are given, and a two-tiered testing system is recommended for a chemical renal toxicity screening program. (Author)