A Study of Adverse Gastrointestinal Effects of 8-Aminoquinolines

摘要

Investigations were carried out to elucidate the mechanism of adverse effects of experimental antimalarial compounds on the gastrointestinal tract. Most of the experimental work used primaquine as a prototype 8-aminoquinoline. This compound was found to have anticholinergic and motility inhibiting effects on the gut from several species. A method for the assessment of the relative potency of these effects was developed and 12 compounds were compared. All compounds tested had significant depressant effect on the motility of the isolated rabbit intestine. These quantitative results may allow comparison of the discomfort producing capacity of the 8-aminoquinoline series when testing in man is possible. (Author)