Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-36325, 1-(Cyclohexylcarbonyl)-Hexahydro-1H-Azepine, AI3-36326, N,N-Dipropyl-Cyclohexanecarboxamide, and AI3-36328, 1-((6-Methyl-3-Cyclohexen-1-YL)Carbonyl)-Pyrro

摘要

Preliminary hazard evaluations of the above candidate repellents were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. None of the compounds caused any phototoxic or skin sensitization reactions, nor were they acutely toxic by ingestion. AI3-36325 and AI3-36328 caused moderate corneal and conjunctival injuries, however, AI3-36326 and AI3-36328 caused mild skin irritation. (Author)