Teratologic Evaluation of a Model Perfluorinated Acid, NDFDA

摘要

The teratogenic effect of a model perfluorinated acid, nonadecafluorodecanoic acid (NDFDA), was evaluated in Fischer 344 rats. Rats were given 0, 5, 10, or 15 mg/kg NDFDA by gavage on Day 9 of gestation. Rats were also treated with 0, 10, 20, or 40 mg/kg NDFDA by gavage on Day 12 gestation. There were no significant differences between treatments and controls at 5, 10, or 15 mg/kg/Day 9 gestation and 10 or 20 mg/kg/Day 12 of gestation. There was a statistically significant decrease in maternal body weight gain, corpora lutea, resorptions, and mean fetal body weight at 30 mg/kg/Day 12 of gestation. There were no significant differences between experimentals and control animals in terms of soft tissue or skeletal abnormalities at any dosage level. (Author)