Primary Dermal Irritation Potential of Components of the M-258A-1 Decontamination Kit.

摘要

The chemical solutions (Decon I and Decon II) used in the M-258A-1 Decontamination Kits were tested for primary dermal irritation potential by using a modified Draize Test on rabbits. The raw solutions were tested both from aged and freshly made kits. The solutions were also tested at concentrations and under conditions simulating expected field use. All studies were conducted in compliance with the Good Laboratory Practices Act. The undiluted solutions caused caustic burns on the animals. At concentrations expected in field use, the solutions were irritating under the classification system used. Both aged and freshly made solutions gave the same results. The irritation caused by the solutions simulating field use, could be alleviated by rinsing the application site with physiologic saline. No assessment was made of the effects on the neutralizing capacity of the solutions by rinsing with saline. (Author)