Quantitative Resolution of Fused Chromatographic Peaks in Gas Chromatography/Mass Spectrometry

摘要

Curve Resolution and the Generalized Inverse Method are used to calculate the molar compositions of mixture mass spectra acquired during coelution of unseparated GC peaks. Quantitative resolution of the GC signal, independent of peak shape, results. The effects of noise, peak separation, a drifting bas line and peak tailing are studied. No assumptions of peak shape or the presence of unique masses for the pure components are required.