Kinetics and Stability of Multicomponent Organophosphate Antidote Formulation in Glass and Plastic

摘要

An aqueous solution of trimedoxime bromide, atropine, and benactyzine hydro-chloride was formulated to have maximum stability as an antidote in organophosphorus poisoning. The stability of the mixture in glass and plastic cartridges was determined. Glass cartridges were more desirable than plastic; there was less vapor loss, color formation, and anomolous reaction. Trimedoxime was stable, losing 1.4% of its potency after 1 year at 25 C and atropine was more stable than trimedoxime. Considerable degradation of benactyzine occurred; 20% of its potency was lost after 1 year at 25 C. Equations for predicting the shelf life of each ingredient at selected temperatures are presented.