The Synthesis and Evaluation of 15-Keto-PGB1 Analogs.

摘要

The initial reaction pathway for the oligomerization of 15-dehydro-PGB1 was determined by the investigation of structurally simpler analogues. This information was used to (1) provide structural insights into the complex oligomeric mixture termed PGBx, (2) develop mild reaction conditions for the conversion of 15-dehydro-PGB1 into less complicated oligomeric mixtures still retaining mitochondrial activity, and (3) design structural modifications that would result in the formation of less complicated oligomeric mixtures that still retain the unique mitochondrial protective effect. (Author)