An Apparatus for the Measurement of Pulmonary Function in Unanesthetized Small Animals

摘要

Because of public and political opinion, rising costs, and regulations, the use of some types of laboratory animals has been limited. As a result, small mammals - in particular, white rats - have become an acceptable alternative to canines for use in toxicological testing. In this report, a method is described by which unanesthetized and comfortably restrained rats are exposed by inhalation to yield fairly complete pulmonary information.