Study of African Trypanosomiasis and Leishmaniasis. Annual Report October 1, 1981 - September 30, 1982 (Final)

摘要

During this period the investigators continued to monitor the antigenic stability of parasites from western Kenya. Studies were conducted to assess the possible role of mechanical transmission in spread of T. rhodesiense. In a cow-cow study it appeared that this mode of transmission is unlikely to play a major role and would not therefore negate a metacyclic vaccine. It is not possible to totally rule out this form of transmission in cow-man or man-man epizootics but the negative data would not support a human volunteer study. In conjunction with local health authorities extensive patient follow up studies have been initiated to determine the extent of treatment failure/relapse and reinfection after a course of therapy recommended by WHO. An experimental model utilizing the goat is being evaluated since it appears that uniform central nervous system disease can be produced in a short period of time. This CNS disease is uniformly fatal if not successfully treated. (Author)