Liposomal-Encapsulated Stroma-Free Hemoglobin as a Potential Blood Substitute

摘要

This contract started as a feasibility study and has involved into a pilot development project. The operational hypothesis is that one can obtain a functional resucitative fluid by encapsulating hemoglobin in physiologically compatible lipid vesicles. We have demonstrated the basic feasibility of the idea. Our objective now is to develop the neohemocyte idea further until we have a prototype product suitable for testing in large animals and man; and we propose studies to do this. One unique approach to minimize acute and chronic toxicity is to design and incorporate into the neohemocyte microcapsule membrane novel masking lipids that may limit neohemocyte interaction with tissues and dramatically retard recognition and clearance by the RES.