Blood Acid-Base Curve Nomogram for Immature Domestic Pigs

摘要

The purpose in this study was to characterize the acid-vase status of arterial blood from healthy young domestic swine and to construct and acid-base curve nomogram appropriate to such animals. Accordingly, 40 immature, 20- to 31-kg domestic pigs were used to establish acid-base characteristics for arterial blood. Hourly measurements over a 6-hour period in 6 of these pigs showed a small, but significant decrease in PO2 with time, but no significant change in acid-base status. The data showed that nomograms or other procedures based on blood characteristics of men were invalid when used to estimate base excess concentration of blood from young pigs. The normal pH of arterial blood was higher in immature pigs than in men; thus, reference values defining zero base excess were not equivalent in men and pigs. Constant PCO2 titrations were performed on arterial samples taken from 10 additional pigs, and the data were used to construct an acid-base curve nomogram. This nomogram was compared with a nomogram for human blood based on constant PCO2 titrations of blood samples from 3 men of variable age with zero base excess. The porcine curve was displaced to the right of the human curve. The higher plasma buffer base concentration of porcine blood, relative to that of human blood, conferred a greater capacity to compensate for acid loads.