Integrative Analysis of Genomewide Gene Expression for Prostate Cancer Prognosis.

摘要

The specific aims of the project have not changed. Using the resources from the Mayo and NYU cohorts, we are conducting: Aim 1. Examine the association of genome-wide mRNA transcription profiles in prostate tumor tissue with PSA recurrence in men who had prostate cancer. We will compare gene expression profile between 400 PSA recurrent men (defined as a follow-up PSA > = 0.20 ng/ml) and 400 non PSA recurrent men. Aim 2. Examine the association of genome-wide mRNA transcription profiles in prostate tumor tissue with systemic progression in men who had a biochemical (PSA) recurrence of prostate cancer. We will compare gene expression profile between 200 systemic progressors (defined as a positive bone scan or CT scan with 5 years of PSA recurrence) and 200 nonprogressors, who remained negative for at least 5 years. Our underlying hypothesis is that mRNA transcription profile plays an important role in shaping phenotypic inter-individual differences in tumor behavior related to prostate cancer prognosis. The ultimate goal of this study is to identify biomarkers that can be used at the time of diagnosis to predict risk of recurrence and improve clinical treatment decision making. Note that the time sequence of tasks is not necessarily the sequence of the study Aims.