Blood Substitutes: Effects on Drug Pharmacokinetics.

摘要

The effect of exhange transfusion with Fluosol DA 20% (FDA) or stroma-free hemoglobin (SFH) on the effectiveness of penicillin therapy of pneumococcal infection and on the pharmacokinetics of antipyrine, diazepam, morphine, penicillin, and sulfamethazine was studied. Penicilline only supresses pneumococcal infection in FDA transfused rats. Transfusion with FDA or SFH does not alter the pharmcokinetics of antipyrine, diazepam, or penicillin. In FDA transfused animals given morphine, the t1/2 and AUC were increased and the Cl was decreased. In FDA transfused animals given sulfamethazine, there was an increase in t1/2 and Vd. In SFH transfused animals given morphine, the t1/2 and Vd were increased. In SFH tranfused animals given sulfamethazine, the AUC was decreased and Cl and Vd were increased. The oxygen-carrying resuscitation fluids alter the pharmacokinetics of morphine and sulfamethazine, but not antipyrine, diazepam, and pencillin. These observations may have important clinical implications. Keywords: Perfluorocarbons.