Korean Hemorrhagic Fever (Hemorrhagic Fever with Renal Syndrome (HFRS)).

摘要

Hemorrhagic fever with renal syndrome (HFRS) was an important military problem since large epidemics of HFRS occurred among soldiers in the past wars. Although predominantly associated with field mice in rural areas, it is now being recognized that urban rats and laboratory rats are also reservoirs of Hantaan virus, the etiologic agent of HFRS, in many parts of the world. This report presents the results of the isolation of Hantaan virus from blood of HFRS patients in tissue culture cells, the serosurvey of Hantaan virus among U.S. soldiers and wild rats caught at the U.S. Army Installations in Korea, and the serosurvey of domestic animals in Korea and neighbouring countries. From blood of HFRS patients, 3 strains of Hantaan virus were isolated in Vero E-6 cells and 19 strains in Apodemus mice. The prevalence rate of IF antibodies to Hantaan virus among 1,986 soldiers stationed in Korea was 1.2% which is a data very similar to that of Seoul residents. Of the 195 wild rats caught at the U.S. Army Installations, 10% had serum antibodies and viral antigen was found in lungs of 2 rats. In domestic animals, If antibodies to Hantaan virus were demonstrated in 3.5% of 792 commercial rabbits, 1 out of 123 chicken and 1 of 104 porcine sera.