Animal Models for the Prevention of Acute and Chronic Graft-versus-Host Disease

摘要

These studies considered the effect on monoclonal antibodies to several T-cell differentiation antigens on graft-versus-host disease in a murine model of bone marrow transplantation. The monoclonal antibodies were used for in vitro treatment of bone marrow and/or spleen cells prior to transplantation and were also used to treat established graft-versus-host disease by in vivo injections. The results increase our understanding of transplantation biology and can form the basis for clinical studies.