Preliminary Assessment of Relative Toxicity and Mutagenic Potential of 1 Nitroso-3,5-Dinitro-1,3,5-Triazacyclohexane (Mononitroso-RDX)

摘要

The munitions component, 1-nitroso-3, 5-dinitro-1,3,5-triazacyclohexane (Mononitroso-RDX), was assessed for its relative irritant, skin sensitization, and mutagenicity potential. It showed no potential for eye or skin irritation in rabbits following a single application. It did not prove to be a skin sensitizer to guinea pigs. Mononitroso-RDX showed positive mutagenic activity in three of four in vitro bioassays. This finding, in addition to its implicating chemical structure, would earmark the chemical as a suspect mutagen and/or carcinogen. Further testing is recommended to establish human risk. Interim protection and monitoring of operational personnel is also recommended until mutagenic/toxicological risks are resolved. (Author).