Aortic Sideport Catheter for Rapid Hemorrhage In Unheparinized Swine

摘要

Rapid hemorrhage is necessary to obtain reproducible mortality in chronically instrumented, unanesthetized, and unheparinized swine. Bleeding catheters could not always deliver the 3.6 ml/kg/min of blood necessary over the 15 minutes required by a rigid experimental design. Catheters become occluded before or during hemorrhage by thrombosis around the outside of the intraaortic portion of the catheter creating a one way valve. By shortening the intraaortic catheter portion to 2 mm from 10 mm and devising an operative technique to insert the catheter the failure rate significantly decreased from 18.8% (n=149). The absence of a significant foreign body surface area in the blood stream allows the aortic sideport catheter to function as a rapid hemorrhage conduit many days later without the use of heparin.