Plasmodium falciparum Antigen That Binds to Host Erythrocytes and Merozoites.

摘要

Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malari parasite) plasmodium falciparum). A 175k antigen was bound only to erythrocytes susceptible to invasion. The 175k antigen from the Camp or the FCR-3 strain was also bound to merozoites. however, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invased normally by merozoites of the homologous strain but were partially resitant to invasion by merozoites of the heterologous strain. The 175k antigen may be a receptor acting as a bridge between erythrocytes and merozoites.