Organophosphorus Ester-Induced Delayed Neurotoxicity: Pathophysiological Alterations in the Primary Sensory Neuron

摘要

The purpose of this contract was to determine whether nerve agents (i.e. soman, sarin, and tabun) produce a delayed neurotoxicity and, if so, what effect they have on the primary sensory neuron and also to determine whether low doses of nerve agent over short periods of time will affect the primary sensory neuron. Cats were administered a large dose of soman or sarin (1 mg/kg, s.c.) along with atropine and physostigmine to protect against cholinesterase poisoning. The cats were examined daily for up to 60 days for signs of delayed neuro-toxicity.