Praziquantel for Treatment of Schistosomiasis in Patients with Advanced Hepatosplenomegaly

摘要

Priziquante was evaluated for therapy of active Schistosoma mansoni infection in 15 rural Egyptian males with hepatosplenic schistosomiasis. Criteria for inclusion in this study were two per-treatment S. mansoni egg counts with a mean of > 100 eggs/g faeces and an enlarged spleen. Fourteen of 15 patients had hepatomegaly, five had ascites, and six had serum albumin below 3 g/dl. Schistosoma haematobium infection ( < 10 eggs/ml urine) was present in three patients. Praziquantel was administered in a single oral dose of 30 mg/kg body weight. Eight of the 15 patients (53%) had mild and transient reactions in the form of fever (usually one day), gastrointestinal symptoms, headache and skin rash. Criteria for parasitological cure were the absence of live eggs in two stool samples and a negative rectal snip biopsy three months after therapy. Ten patients ceased to pass live eggs (cure rate 67%). For the five who were still passing live eggs there a mean egg reduction of 95%. Praziquantel is an effective and well tolerated drug for treatment of S. mansoni infection in patients with advanced hepatosplenic schistosomiasis, and it is the drug of choice for patients with coexisting S. haematobium infection.