Biodegradable Implant for Restoring Bone Discontinuity Defects in Dogs.

摘要

A copolymer (polylactic acid: polyglycolic acid) was combined with a proteolipid (PL) and the resulting implant complex was rigidly fixed into discontinuities in the mandibles of 25 adult, foxhound dogs. Identically prepared control discontinuities in contralateral sites in the same animals did not receive the complex and were rigidly fixed. At 4, 8, 12, 24, 40 weeks the dogs were sacrificed and implant and controls were prepared for histomorphometry. Histomorphometric evaluation revealed there was a linear increase of bony reparative elements in the implants over 40 weeks that exceeded those of the nontreated control sites. The copolymer-PL implant, therefore, may provide an alternative to autogeneic and allogenic bone substances. (Author)