Treatment of Bilharzial Colonic Polyposis with Praziquantel

摘要

Previously published data indicate the effective use of niridazole(AMBILLAR) in the treatment of patients with schistosomal colonic polyposis. However, severe side effects, which included neuromuscular and psychoti c reactions, were noted in >90% of the patients. For this reason the efficacy ofother less toxic antischistosomal drugs was evaluated specifically in regard to the teatment of colonic polyposis. The present study compared oxamniquine (VANSIL) and Praziquantel (BILTRICIDE). Twenty-two Egyptian males aged 11-52 years presented with bloody diarrhea. they were found to be infected with Schistosoma mansoni and had friable, bleeding, and purulent colonic polyps, as detected by sigmoidoscopy and air-contrast barium enema. These data reveal that the cure rates with praziquantel were the same as they were with oxamniquine. However, the degree of improvement-reduction in size of the colonic polyps and clearing of the friable mucous membrane-appeared to be better with praziquantel, although not statistically different from oxamniquine. Because praziquantel was previously found to be effective in relief of bilharzial obstructive uropathy, it may be the drug of choice in the treatment of these particular sequelae of infections with either S. mansoni or Schistosoma haematobium.