Discriminant Function Analysis of Genetic Traits Associated with Leishmania major Infection in the CXS Recombinant Inbred Strains

摘要

BALB/c mice are susceptible to Leishmania major infections: these mice develop nonhealing cutaneous lesions at the site of inoculation, and infections metastasize to the lymph nodes, spleen and liver after 4-6 weeks. By 10-12 weeks, the infected foot sloughs off and 80% of the mice die. In contrast, C57Bl/6ByJ and STS/A mice are resistant to L. major; they develop neither cutaneous lesions nor systemic metastases over a 12 week period. Recombinant inbred strains initially derived by mating BALB/c with C57bl/CvyJ (CXB) and STS/A (CXS) mice were typed for their expression of cutaneous and systemic susceptibility to L. major amastigotes administered sc in the footpad. Typing of the CXB and CXS recombinant inbred strains revealed that at least two genes are involved in the control of L. major infection. The development of a nonhealing cutaneous lesion among the various mouse strains wer not 100% concordant with the development of systemic disease.