Early Initial Antibiotics and Debridement Independently Reduce Infection in an Open Fracture Model.

摘要

Most animal studies indicate that early irrigation and debridement reduce infection after open fracture. Unfortunately, these studies often do not involve antibiotics. Clinical studies indicate that the timing of initial debridement does not affect the rate of infection but these studies are observational and fraught with confounding variables. The purpose of this study was to control these variables using an animal model incorporating systemic antibiotics and surgical treatment.