Stability of T-2 Mycotoxin in Aqueous Media

摘要

Radiolabeled (3H)T-2 mycotoxin was dissolved in various aqueous media and stored for up to 3 weeks at 4,22, and 37 C. At periods ranging from 1 to 21 days, aliquots were assayed by thin layer chromatography. Breakdown products were identified based on their co-migration with known standards. Results indicated that T-2 toxin was most stable in tissue culture medium with or without serum, compared to HBSS, at all temperatures. The metabolites HT-2, T-2 triol, and T-2 tetraol were detected in decreasing concentrations, as early as 1 day (HBSS, 37 C) and as late as 3 weeks (HBSS, 4 C). Stability of the toxin in aqueous media decreased with increasing temperature.