Inhalation Toxicology. 4. Times to Incapacitation and Death for Rats Exposed Continuously to Atmospheric Hydrogen Chloride Gas

摘要

Laboratory rats were exposed continuously to measured atmospheric concentrations of hydrogen chloride (HC1) gas until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel. These two endpoints, time-to-incapacitation and time-to-death, were equated to atmospheric HC1 concentration by statistically derived regression equations. The possible relationship between the effective toxic doses of HC1 gas for rats and those reported for humans is discussed.