Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma.

摘要

Purpose, scope, significant findings, progress Heterotopic ossification has been associated with numerous factors, however, there has been no conclusive evidence that a given environmental element is causative. We propose that certain individuals are genetically predisposed toward an altered sympathetic response to trauma which not only contributes to post-traumatic morbidity but also the formation of heterotopic bone. We have genotyped 2869 patients admitted to a Level I trauma center ICU for alleles that may be associated with bone healing, autonomic regulation and inflammation. Our preliminary results in a subset of 1313 patients have shown an association of a minor allele of the 2 adrenergic receptor with HO formation. Furthermore, the patients who formed HO also were more likely to have had a prolonged ICU stay and days on a ventilator independent of a higher ISS score which was also associated with HO. Head injury, as defined by the AIS head score, however, was inversely correlated with HO. We have now completed the data collection on 244 SNPs in 2869 individuals and are awaiting final analysis of this data.