Dietary Regulation of PTEN Signaling and Mammary Tumor Initiating Cells: Implications for Breast Cancer Prevention.

摘要

Mammary steam cells (MaSC) are required for tissue homeostatis and epithelial expansion during the development; however, dysregulatoon of MaSC self-renewal such as by Wnt1 overexpression leads to neoplastic transformation. To date, in vivo dietary regulation of MaSC and its relation to breast cancer has not been evaluated. Therefore, I proposed to investigate the effect of lifetime intake of soy protein (SPI) diet relative to the control casein (CAS) diet on mammary steam cell (MaSC) population and its correlation to tumor formation in MMTV-Wnt1-Transgenic female mice. TYumor incidence was lower in SPI fed Wnt1-Tg mice relative to those fed CAS (48.3% vs. 73.5%; p less 0.05).