Ovarian Mouse Models with Targeted Fallopian Tubal Carcinogenesis.

摘要

To test the idea that ovarian cancer arises from oviductal epithelium, spreads to the ovary, and presents as ovarian cancer, we generated a mouse model in which we can target genetic deletions to the oviductal epithelium. We are currently performing selective genetic deletion of ovarian cancer genes, such as TP53, Rb, and BRCA1 in oviductal epithelium in this mouse model.