Genotoxicity of Dyes Present in Colored Smoke Munitions

摘要

The Lovelace Inhalation Toxicology Research Institute has been coduction genetic toxicology studies on organic dyes used in colored smoke munitions. This report summarizes the results of tests to determine the genotoxic potency of the dyes toward both bacteria and mammalian cells in vitro. The tests were conducted to detect mutations in bacteria and mammalian cells and to determine cell killing, alterations in cell cycle kinetics, sister chromatid exchanges, and chromosome aberration induction in mammalian cells. The dyes evaluated in the report include Solvent Red 24, Solvent Red 1, Disperse Red 11 and terephthalic acid. Disperse Red 11 had chemical contamination that seemed to be responsible for some mutagenic activity. Keywords: Disperse Red 11, Solvent Red 24, Solvent Red 1, Genotoxicity, Dyes, Disperse Red 15.