CXCR/EGFR Axis in the Initiation and Progression of Prostate Cancer.

摘要

CXCL12 is a small molecular weight protein secreted by fibroblasts in the prostate stroma consequent to aging and activates CXCR4, a G-protein coupled receptor expressed in prostate epithelial cells. Activation of the CXCL12/CXCR4 axis has been shown to promote prostate cancer cell proliferation, motility, and invasiveness; furthermore, previous reports have shown phosphorylation of EGFR and HER2 in response to CXCL12 treatment. Here I examined the dimerization of EGFR and HER2 in response to varying concentrations of CXCL12. Although some instances of heterodimerization were observed using co-IP, there was no consistency in responses to specific concentrations and observed dimerization with CXCL12 treatment was not as robust as with EGF treatment; thus, these data are inconclusive and I am unable to report novel significant findings.