Amodiaquine Less Effective than Chloroquine in the Treatment of Falciparum Malaria in the Philippines

摘要

Amodiaquine was compared to chloroquine in two groups of Filipino patients with uncomplicated falciparum malaria. Every patient received 25 mg/kg of base orally given over three days. In a hospital study, all 8 patients receiving chloroquine cleared their parasitemia by day 6, but 6 of 8 patients receiving amodiaquine failed to clear parasitemia and in 4 patients there was no response at all (RIII resistance); this difference was significant (P<0.01). in a village based study, there was initial clearing of parasitemia in each patient. However, recrudescent infection occurred in all 5 patients receiving amodiaquine (RI resistance). 5 of 6 falciparum infections were sensitive to chloroquine, while parasitemia reappeared in one patient. In this village, resistance to amodiaquine was significantly more common than resistance to chloroquine (PL0.05). To our knowledge, this is the first report of amodiaquine being substantially worse thatn chloroquine in the treatment of Plasmodium falciparum infection.