Aztreonam in the Treatment of Enteric Fevers. (Reannouncement with New Availability Information).

摘要

In this report, we present preliminary data on the use of the monobactam, aztreonam, in the treatment of bacteriologically proven Salmonella typhi and S. paratyphi A septicaemia. Eleven patients, five adults (four females and one male) aged 14 to 29 years, and six children (two females and four males) aged six to nine years were treated with aztreonam. S. typhi was cultured from the blood of ten patients and S. paratyphi A from one patient. All isolates were sensitive to aztreonam by the disc diffusion method. Aztreonam was administered intramuscularly every eight hours in a dose of 50 mg kg - 1 dose - 1 (max. 8 g) for a minimum of seven days. All patients had been ill for at least four days before referral to hospital. All were highly toxic and irritable, and five were disoriented.