Genome Wide Association Study to Identify SNPs and CNPs Associated with Development of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy.

摘要

The hypothesis that forms the basis for this research is that patients who possess certain SNPs or CNPs are at a greater risk for developing severe urinary morbidity or erectile dysfunction (ED) resulting from radiotherapy for prostate cancer. The specific aim of this project was to identify through a genome wide association study the SNPs and CNPs associated with the development of these adverse effects resulting from the use of radiation to treat prostate cancer. We have performed a two-stage genome-wide association study and identified and validated loci associated with each of these primary outcomes. It is expected that the results of this work will provide the basis for a clinically relevant predictive test to identify patients at increased risk for development of adverse events following radiotherapy. It is anticipated that such a tool will be used to aid clinicians in personalizing treatment to improve the therapeutic outcome for men diagnosed with prostate cancer.