Chlorotrifluoroethylene Oligomer: Evaluation of Acute Delayed Neurotoxicity in Hens, and Study of Absorption and Metabolism in Rats Following Oral, Dermal, and Inhalation Exposure

摘要

Acute toxicity studies including delayed neurotoxicity, single dose oral, 4- and 6-hour vapor inhalation, and single dose dermal were conducted with the chlorotrifluoroethylene (CTFE) oligomer MLO 83-322. A second sample, MLO 81-125 from the same lot as MLO 83-322, did not contain the additives and was used only during part of the inhalation study. Hens receiving five consecutive oral doses of up to 9.2 g CTFE/kg body weight remained neurologically asymptomatic through a 30 day observation period. CFTE was readily absorbed and converted to free fluoride following oral and inhalation exposure. Single oral doses of 9.2 g CFTE/kg failed to produce mortality in the test rats. Six-hour saturated vapor exposures to MLO 83-322 resulted in mortality while four-hour exposures caused no deaths. Four-hour inhalation exposures to MLO 81-125 produced deaths at both concentrations tested. CTFE absorption was not evident following dermal exposure.