Catalysis of G Agent Hydrolysis in Micellar Solutions of o-Iodosobenzoic Acid

摘要

Several recent reports have demonstrated that o-iodosobenzoic acids (o-IBA) can function as highly effective nucleophilic catalysts for the hydrolysis of organophosphorus (OP) esters. Consequently, considerable interest in this class of compounds as catalysts for nerve agent destruction has been generated within the defence science community. However, the number of OP ester substrates used to determine the efficiency of these catalysts was limited and did not include any of the nerve agents GA, GB or GD. Furthermore, it was noted that catalysis by 0-IBA's in the absence of cationic micelles is unremarkable. Rate acceleration in micellar solutions arises from differing rated of reaction of the substrate in the bulk aqueous and micellar phases as well as the partitioning of the substrate between these phases (4). This partitioning of substrate depends upon its hydrophobic and electrostatic interactions with the micelles. Chemical warfare agents, Australia. (jes)